In-Liquid Imaging

Scanning Ion Conductance Microscopy (SICM)

Scanning Ion Conductance Microscopy (SICM) utilizes a pipette with a nanometer-scale aperture. The ion current between the inside and the outside of the pipette in aqueous solution changes depending on the distance from the nanopipette tip to the surface. The topography is acquired by using a feedback controller to hold the ion current constant.